General
Preferred name
tropisetron
Synonyms
SDZ-ICS 930 ()
Tropisetron HCl ()
ICS 205-930 ()
Tropisetron (Hydrochloride) ()
SDZ-ICS-930 ()
SDZ-ICS-930 (free base) ()
TROPISETRON HYDROCHLORIDE ()
Tropisetron (hydrochloride) ()
Tropisetron (as hydrochloride) ()
Navoban ()
ICS-205-930 ()
Novaban ()
NSC-759842 ()
Tropisetron monohydrochloride ()
Tropisetron-d5 ()
P&D ID
PD013759
CAS
89565-68-4
105826-92-4
1220284-86-5
Tags
available
drug
First approval
1992
Drug Status
investigational
approved
Max Phase
3.0
Drug indication
Nausea
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an ¦Á7-nAChRreceptor agonist, with an IC50 of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation[1][2][3][4].
PRICE 40
DESCRIPTION There is some ambiguity in the literature as to the exact stereochemistry of tropisetron. The structure shown here matches the INN-assigned structure and is the same as the the ChEBI and ChEMBL entries linked to above. There is no exact match in PubChem for the structure shown here. (GtoPdb)
DESCRIPTION Tropisetron (SDZ-ICS-930 free base) is an orally active anti-inflammatory and antiemetic agent. Tropisetron is 5-HT3R antagonists with a Ki of 5.3 nM. Tropisetron is also a partial agonist of ¦Á7 nicotinic receptor (¦Á7 nAChR) with an EC50 of 1.3 ¦ÌM. In addition, Tropisetron has antitumor and neuroprotective effects[1][2][3][4][5][6].
DESCRIPTION Tropisetron hydrochloride (Tropisetron HCl) is the hydrochloride salt form of tropisetron, a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, with antinauseant and antiemetic activities. (TargetMol Bioactive Compound Library)
DESCRIPTION Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy-and radiotherapy-induced nausea and vomiting. It is used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
21
Cayman Chemical Bioactives
21240
30736
ChEMBL Drugs
CHEMBL56564
Concise Guide to Pharmacology 2017/18
260
Concise Guide to Pharmacology 2019/20
260
Concise Guide to Pharmacology 2021/22
260
Concise Guide to Pharmacology 2023/24
260
Drug Repurposing Hub
DrugBank
DB11699
DrugBank Approved Drugs
DB11699
DrugCentral
2775
DrugCentral Approved Drugs
2775
Enamine Bioactive Compounds
EBC-09042
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100327
Guide to Pharmacology
260
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL56564
MedChem Express Bioactive Compound Library
HY-B0020
HY-B0072
NIH Clinical Collections (NCC)
NPC Screening Collection
Selleckchem Bioactive Compound Library
tropisetron
TargetMol Bioactive Compound Library
T1173
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
284.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
2.95
TPSA
45.33
Fraction CSP3
0.47
Chiral centers
3.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT
5-HT Receptor
GLRA1, GLRA2, GLRB, HTR3A, HTR4
nAChR
AP-1
JAK
NF-κB
Nuclear Factor of activated T Cells (NFAT)
p38 MAPK
5-HT Receptor,AChR
MOA
5-HT Receptor antagonist
serotonin receptor antagonist
Indication
nausea, vomiting
Pathway
GPCR/G protein
Membrane Transporter/Ion Channel
Neuronal Signaling
Epigenetics
Immunology/Inflammation
JAK/STAT Signaling
MAPK/ERK Pathway
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Neuroscience
NF-¦ÊB
Source data