General
Preferred name
imidapril
Synonyms
Novaloc ()
Imidapril HCl ()
Tanapril ()
TA-6366 ()
imidapril hydrochloride, Ark ()
Imidapril (hydrochloride) ()
TA-6366 (free base) ()
Imidapril hydrochloride ()
Imidapril monohydrochloride ()
TA 6366 ()
Hipertene ()
Tanatril ()
P&D ID
PD013736
CAS
89396-94-1
89371-37-9
Tags
available
prodrug
drug
First approval
1993
Drug indication
Cardiovascular disease
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research[1][2].
PRICE
42
DESCRIPTION
Imidapril is an ACE inhibitor, administered as a prodrug which is then metabolised to the active form, imidaprilat.
(GtoPdb)
DESCRIPTION
Imidapril hydrochloride (Tanapril) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
405.19
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
2
Aromatic Ring Count
1
cLogP
0.88
TPSA
116.25
Fraction CSP3
0.5
Chiral centers
3.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACE
Angiotensin-converting Enzyme (ACE)
MMP
ACE,RAAS
Indication
hypertension, congestive heart failure
MOA
angiotensin converting enzyme inhibitor
Pathway
Metabolic Enzyme/Protease
Endocrinology/Hormones
Source data
