General
Preferred name
ADEFOVIR
Synonyms
PMEA ()
GS-0393 ()
GS0393 ()
GS 0393 ()
Adefovir-d4 ()
P&D ID
PD013718
CAS
106941-25-7
1190021-70-5
Tags
available
prodrug
drug
Drug indication
Discovery agent
Herpes simplex virus infection
chronic hepatitis B virus infection
Hepatitis B virus infection
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil. It inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
8
Organisms
12
Compound Sets
14
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
273.06
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.44
TPSA
136.38
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
hepatitis B
MOA
DNA polymerase inhibitor
Target
HBV
Reverse Transcriptase
Pathway
Anti-infection
Source data
