General
Preferred name
SEMATILIDE
Synonyms
CK-1752A ()
CK-1752 ()
Sematilide HCl ()
Sematilide monohydrochloride monohydrate ()
Sematilide (hydrochloride) ()
CK-1752 (hydrochloride) ()
SEMATILIDE HYDROCHLORIDE ()
Sematilida ()
Sematilide monohydrochloride ()
P&D ID
PD013714
CAS
101526-83-4
101526-62-9
Tags
drug candidate
available
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
52
DESCRIPTION
Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
Cayman Chemical Bioactives
ChEMBL Drugs
DrugMatrix
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
313.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
1
Aromatic Ring Count
1
cLogP
1.13
TPSA
78.51
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
K+ current (IKr)
Potassium Channel
K+ current (IKr) channel
MOA
Others inhibitor
Pathway
Membrane Transporter/Ion Channel
Source data
