General
Preferred name
VARENICLINE
Synonyms
CP 526555-18 ()
Champix tartrate ()
Chantix tartrate ()
VARENICLINE TARTRATE ()
Varenicline (dihydrochloride) ()
Varenicline (Hydrochloride) ()
Varenicline (Tartrate) ()
CP 526555 ()
CP 526555 (dihydrochloride) ()
CP 526555 hydrochloride ()
Varenicline Tartrate (CP 526555-18) ()
Varenicline Hydrochloride ()
Varenicline (CP 526555) dihydrochloride ()
Chantix, Champix,CP 526555-18 ()
Chantix, Champix,CP 526555 dihydrochloride ()
Chantix, Champix,CP 526555 ()
Varenicline dihydrochloride ()
Chantix ()
CP-526555 ()
CP-526,555 ()
CP-526,555-18 ()
CP-526555-18 ()
Champix ()
Tyrvaya ()
Varenicline-d4 ()
P&D ID
PD013697
CAS
866823-63-4
375815-87-5
249296-44-4
230615-23-3
2183239-01-0
Tags
natural product
drug
available
Drug Status
investigational
approved
Drug indication
Smoking dependence
Max Phase
Phase 4
First approval
2006
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Varenicline dihydrochloride is an α4β2 nicotinic acetylcholine receptor partial agonist. Varenicline is a prescription medication used for smoking cessation. (BOC Sciences Bioactive Compounds)
DESCRIPTION Varenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking. (BOC Sciences Bioactive Compounds)
Compound Sets
16
AdooQ Bioactive Compound Library
A10966
BOC Sciences Bioactive Compounds
varenicline-dihydrochloride-cas-866823-63-4-55393
varenicline-hydrochloride-cas-230615-23-3-item-84-312697
Cayman Chemical Bioactives
15030
26102
ChEMBL Approved Drugs
CHEMBL1396
CHEMBL2062259
ChEMBL Drugs
CHEMBL1396
CHEMBL2062259
DrugBank
DB01273
DrugBank Approved Drugs
DB01273
DrugMAP
DMMUOLJ
DrugMAP Approved Drugs
DMMUOLJ
EU-OPENSCREEN Bioactive Compound Library
EOS100901
Ki Database
varenicline
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1396
MedChem Express Bioactive Compound Library
HY-10021
HY-10019
HY-10019A
HY-10020
NPC Screening Collection
Selleckchem Bioactive Compound Library
Varenicline-tartrate
varenicline
varenicline-dihydrochloride
varenicline-hydrochloride
TargetMol Bioactive Compound Library
T1657
T4246
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
211.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
1.8
TPSA
37.81
Fraction CSP3
0.38
Chiral centers
2.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
MAPK/ERK Pathway
Stem Cell/Wnt
Target
??4??2 nAChR
mAChR
¦Á4¦Â2 nAChR
nAChR
ERK
p38 MAPK
MOA
AChR
AChR antagonist
Source data