General
Preferred name
Zimelidine
Synonyms
ZIMELDINE ()
ZIMELIDINE DIHYDROCHLORIDE ()
ZIMELDINE HYDROCHLORIDE ()
Zimelidine (dihydrochloride) ()
Zimeldina ()
Cis-zimelidine ()
Zelmid ()
Normud ()
Zimeldine dihydrochloride monohydrate ()
H 102/09 HYDROCHLORIDE ()
H-102/09 HYDROCHLORIDE ()
Zimeldine hcl ()
Zimelidine hydrochloride ()
P&D ID
PD013694
CAS
56775-88-3
60525-15-7
61129-30-4
Tags
available
drug
Drug indication
Major depressive disorder
Depression
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
Zimelidine was the first marketed selective serotonin reuptake inhibitor (SSRI) antidepressant. It is a pyridylallylamine, structurally different from other antidepressants.
MOA
The antidepressant actions of zimelidine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Zimelidine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
INDICATION
For the treatment of depression.
HALF-LIFE
8.4 +/- 2.0 hours for the parent compound and 19.4 +/- 3.6 hours for norzimelidine.
DESCRIPTION
Zimelidine dihydrochloride is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine dihydrochloride is an antidepressant[1].
DESCRIPTION
Serotonin reuptake inhibitor; antidepressant
(LOPAC library)
DESCRIPTION
Selective 5-HT uptake inhibitor
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
16
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
LOPAC library
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
ReFrame library
Tocriscreen Total
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
316.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
3.84
TPSA
16.13
Fraction CSP3
0.19
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
Target
MAOA, MAOB, SLC6A4
5-HT Receptor
Serotonin Transporter
MOA
selective serotonin reuptake inhibitor (SSRI)
ATC
N06AB02
Toxicity type
neurological, dermatological
Pathway
GPCR/G protein
Neuronal Signaling
Source data
