General
Preferred name
CLOMETHIAZOLE
Synonyms
Clomethiazolum ()
Chlormethiazole hydrochloride ()
CLOMETHIAZOLE EDISILATE ()
Distraneurin ()
Chlormethiazole ()
5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE ()
Clomethiazole hydrochloride ()
clomethiazole, AstraZeneca ()
Clometiazol ()
Heminevrin ()
Distraneurine ()
Chlormethiazole (hydrochloride) ()
P&D ID
PD013687
CAS
533-45-9
6001-74-7
Tags
available
drug
First approval
1981
Drug indication
Anxiety
Stroke
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chlormethiazole is an potent and orally active GABAA?agonist[1]. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].
DESCRIPTION
Clomethiazole hydrochloride is a anticonvulsant. Clomethiazole hydrochloride is neuroprotective and prevents the degeneration of serotonergic nerve terminals induced by 3,4-methylenedioxymethamphetamine (MDMA)[1][2].
PRICE
29
DESCRIPTION
Chlormethiazole is an potent and orally active GABAA agonist. It inhibits cytochrome P450 isoform CYP2E. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus.
(Enamine Bioactive Compounds)
DESCRIPTION
Chlormethiazole hydrochloride is the hydrochloride salt of chlormethiazole, which is a GABAA agonist. It is a useful research chemical and is used in the study of effects of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system. It is neuroprotective in a number of animal models and is used as a sedative and anticonvulsant. It prevents the degeneration of serotonergic nerve terminals induced by MDMA.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potentiates GABAA receptor function
(Tocriscreen Total)
DESCRIPTION
Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Chlormethiazole hydrochloride is an anticonvulsant and sedative. It also has neuroprotective.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
16
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
NPC Screening Collection
ReFrame library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
161.01
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
2.23
TPSA
12.89
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
5.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CYP2A6
CYP2E1
Cytochrome P450
GABA Receptor
GABAA
GABRA1
Indication
Parkinson's Disease, sedative, muscle relaxant
MOA
GABA receptor antagonist, GABA receptor modulator
Pathway
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
