General
Preferred name
CLOMETHIAZOLE
Synonyms
Clomethiazolum ()
Chlormethiazole hydrochloride ()
CLOMETHIAZOLE EDISILATE ()
clomethiazole, AstraZeneca ()
Clomethiazole hydrochloride ()
Chlormethiazole ()
Distraneurine ()
Heminevrin ()
SCTZ [As Edisylate] ()
Chlormethiazole (hydrochloride) ()
P&D ID
PD013687
CAS
533-45-9
6001-74-7
Tags
available
drug
First approval
1981
Drug indication
Stroke
Drug Status
investigational
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chlormethiazole hydrochloride is the hydrochloride salt of chlormethiazole, which is a GABAA agonist. It is a useful research chemical and is used in the study of effects of thiazole methiodide and hydrochloride fractions of thiamine upon the neuromuscular system. It is neuroprotective in a number of animal models and is used as a sedative and anticonvulsant. It prevents the degeneration of serotonergic nerve terminals induced by MDMA.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potentiates GABAA receptor function
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Enamine BioReference Compounds
NPC Screening Collection
ReFrame library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
161.01
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
2.23
TPSA
12.89
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
5.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
Parkinson's Disease, sedative, muscle relaxant
MOA
GABA receptor antagonist, GABA receptor modulator
Target
GABRA1
Cytochrome P450
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
