General
Preferred name
QUINUPRISTIN
Synonyms
Synercid-quinupristin ()
Quinupristin (mesylate) ()
Quinupristina ()
Quinupristine ()
RP-57669 ()
RP 57669 ()
Quinupristin component of synercid ()
P&D ID
PD013593
CAS
120138-50-3
Tags
available
drug
Approved by
FDA
First approval
1999
Drug indication
osteomyelitis
Bacterial infection
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
METABOLISM
Quinupristin is converted to two conjugated active major metabolites, one with ; glutathione and one with cysteine.
DESCRIPTION
Quinupristin is a semi-synthetic derivative of streptogramin B. It inhibits the late stage of protein synthesis by binding to the bacterial 50S ribosomal subunit.
(GtoPdb)
DESCRIPTION
Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits[1] [2].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
1021.47
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
4
Rotatable Bonds
10
Ring Count
9
Aromatic Ring Count
3
cLogP
2.32
TPSA
231.2
Fraction CSP3
0.53
Chiral centers
9.0
Largest ring
19.0
QED
0.21
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Biosynthetic Origin
Peptide (NRPS), Polyketide
Therapeutic Indication
Antibacterial
Therapeutic Class
Antimicrobial
Antibiotics
Target
antibiotic
Bacterial
Pathway
Anti-infection
Source data
