General
Preferred name
EDOXUDINE
Synonyms
Aedurid ()
EUDR ()
Epoxudine ()
RWJ-15817 ()
NSC-758405 ()
Edoxudina ()
ORF 15817 ()
ORF-15817 ()
RWJ 15817 ()
5-ethyl-3-(2'-deoxyribosyl)uracil ()
EDU ()
P&D ID
PD013548
CAS
15176-29-1
Tags
available
drug
Drug indication
Discovery agent
viral disease
Drug Status
approved
withdrawn
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Edoxudine was used in Europe, in the form of a topical antiviral, for the treatment of human herpes keratitis.[A32643] Human herpes keratitis is an inflammation of the cornea in the eye caused by herpes simplex virus infection. This infection is a cause of significant morbidity whose incidence is significantly increased in the presence of recurrent infection and it can even produce corneal blindness.[A32645]; ; Edoxudine 3% cream was also indicated for the treatment of dermal herpes simplex virus.[A32643] This virus can produce an infection ubiquitously and it is highly contagious. There are two types of herpes virus, type 1 that is mainly transmitted by oral-to-oral contact and type 2 that is sexually transmitted.[L2411]
PRICE 38
DESCRIPTION Edoxudine (Epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. Edoxudine is used as a 5-fluorouracil (FU) modulator. Edoxudine may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels. It can also enhance the antitumour action of 5-FU. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
6
Compound Sets
11
ChEMBL Drugs
CHEMBL318153
Drug Repurposing Hub
DrugBank
DB13421
DrugBank Approved Drugs
DB13421
DrugCentral
3173
DrugCentral Approved Drugs
3173
DrugMAP
DMC7DYX
EU-OPENSCREEN Bioactive Compound Library
EOS100073
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T4374
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
256.11
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
-1.26
TPSA
104.55
Fraction CSP3
0.64
Chiral centers
3.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antiviral
Bacterial
Indication
virus herpes simplex (HSV)
MOA
DNA directed DNA polymerase inhibitor
Pathway
Immunology/Inflammation
Microbiology/virology
Source data