General
Preferred name
MIFOBATE
Synonyms
SR-202 ()
SR 202 ()
SR 202 ()
Mifobato ()
Clenicor ()
Claniclor ()
P&D ID
PD013547
CAS
76541-72-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Mifobate (SR-202) is a potent and specific PPAR¦Ã antagonist. Mifobate (SR-202) selectively inhibits Thiazolidinedione (TZD)-induced PPAR¦Ã transcriptional activity (IC50=140 ¦ÌM). Mifobate (SR-202) does not affect basal or ligand-stimulated transcriptional activity of PPAR¦Á, PPAR¦Â, or the farnesoid X receptor (FXR). Mifobate (SR-202) shows antiobesity and antidiabetic effects[1].
PRICE
146
DESCRIPTION
Mifobate (SR-202) is a potent and specific antagonist of PPAR??, exhibiting antiobesity, antidiabetic, and antiatherosclerotic effects[1].
DESCRIPTION
SR 202 is a selective PPARγ antagonist used as an antidiabetic and antiobesity agent. SR 202 inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo, improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective PPARγ antagonist; antidiabetic and antiobesity agent
(Tocriscreen Total)
DESCRIPTION
Mifobate (SR-202) is a potent and specific antagonist of PPARγ, exhibiting antiobesity, antidiabetic, and antiatherosclerotic effects[1].
(TargetMol Bioactive Compound Library)
DESCRIPTION
Potent, selective PPARgamma partial agonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
DrugMatrix
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
358.01
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
1
Aromatic Ring Count
1
cLogP
4.24
TPSA
80.29
Fraction CSP3
0.45
Chiral centers
1.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PPAR
PPARγ
Primary Target
PPAR?
MOA
Antagonist
PPARgamma Antagonists
Member status
member
Pathway
DNA Damage/DNA Repair
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data
