General
Preferred name
SISOMICIN
Synonyms
Pathomycin ()
Extramycin ()
Sisomicin (sulfate) ()
Antibiotic 6640 ()
Rickamicin ()
SISOMICIN SULFATE ()
Sisomicin ()
Fosamprenavir (calcium salt) ()
Sissomicin ()
SCH 13475 SULFATE ()
SCH-13475 SULFATE ()
Sch 13475 sulphate ()
Sissomicin sulfate ()
NSC-757315 ()
Sisomicin sulphate ()
Sisomicine ()
SCH 13475 ()
Sisomicina ()
P&D ID
PD013537
CAS
32385-11-8
53179-09-2
226700-81-8
Tags
available
drug candidate
natural product
drug
First approval
1977
Drug Status
approved
investigational
Max Phase
3.0
Drug indication
bacterial disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sisomicin is a naturally occurring aminoglycoside antibacterial that has activity against Gram-positive and Gram-negative bacteria . It is produced by Micromonospora inyoensis. It is active against some microorganisms that are resistant to other aminoglycosides, and offers synergistic activity against enterococci, staphylocicci, Enterobacteriaceae, and nonfermentative gram-negative bacilli when combined with beta-lactam antibacterials.
(GtoPdb)
DESCRIPTION
Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria[1][2].
DESCRIPTION
Sisomicin Sulfate (Pathomycin) is the sulfate salt form of sisomicin, a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. Sisomicin is structurally similar to gentamicin but has a unique unsaturated diamino sugar. Of the aminoglycoside antibiotics, sisomicin has the greatest activity against gram-positive bacteria.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
Guide to Pharmacology
NPC Screening Collection
Other bioactive compounds
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
447.27
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
8
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
0
cLogP
-3.85
TPSA
213.72
Fraction CSP3
0.89
Chiral centers
11.0
Largest ring
6.0
QED
0.2
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
protein-synthesis
Antibiotics
Indication
gram-negative bacterial infections
conjunctivitis, punctate keratitis
MOA
bacterial 30S ribosomal subunit inhibitor
protein synthesis inhibitor
Pathway
Microbiology/virology
Anti-infection
Source data
