General
Preferred name
CEVIMELINE
Synonyms
AF-102B hydrochloride ()
SNI-2011 hydrochloride ()
AF-102B ()
Cevimeline hydrochloride hemihydrate ()
Cevimeline hydrochloride ()
Cevimeline (hydrochloride) ()
Cevimeline (hydrochloride hemihydrate) ()
(-)-Cevimeline (hydrochloride hemihydrate) ()
AF102B ()
AF102B (hydrochloride) ()
SNI-2011 ()
AF102B (hydrochloride hemihydrate) ()
(-)-SNI-2011 ()
(-)-AF102B (hydrochloride hemihydrate) ()
P&D ID
PD013516
CAS
153504-70-2
124620-89-9
107220-28-0
107233-08-9
1035535-90-0
Tags
available
drug
Drug indication
Sjogren syndrome
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB)[5].
DESCRIPTION Cevimeline is a selective M1 receptor agonist. (BOC Sciences Bioactive Compounds)
Compound Sets
9
BOC Sciences Bioactive Compounds
cevimeline-cas-107233-08-9-item-84-53965
Cayman Chemical Bioactives
17802
DrugMAP
DMWSMND
DrugMAP Approved Drugs
DMWSMND
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100068
MedChem Express Bioactive Compound Library
HY-70020B
HY-70020
HY-76772B
HY-76772
NPC Screening Collection
ReFrame library
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
199.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
1.56
TPSA
12.47
Fraction CSP3
1.0
Chiral centers
2.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mAChR
Therapeutic Class
Parasympathomimetics
Pathway
GPCR/G protein
Neuronal Signaling
Source data