General
Preferred name
THONZYLAMINE
Synonyms
THONZYLAMINE HYDROCHLORIDE ()
2-((2-(Dimethylamino)ethyl)(4-methoxybenzyl)amino)pyrimidine ()
Resistab ()
Thonzylamine HCl ()
Novohetramin ()
Neohetramine hydrochloride ()
Anahist ()
neohetramine ()
Super anahist ()
Thonzylamine hcl ()
NSC-758388 ()
Tonamil ()
Tonzilamina ()
P&D ID
PD013508
CAS
63-56-9
91-85-0
Tags
available
drug candidate
drug
Drug Status
approved
investigational
Max Phase
2.0
Drug indication
Pruritus
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
57
DESCRIPTION
Thonzylamine is an orally active H1 histamine receptor antagonist with good antihistaminic and antianaphylactic properties. Thonzylamine can be used for the research of hypersensitivity diseases, nasal congestion, allergic conjunctivitis and other allergic diseases[1][2].
PRICE
47
DESCRIPTION
Thonzylamine hydrochloride (Resistab) is an anticholinergic and antihistamine used as an antipruritic.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Thonzylamine (neohetramine) is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
286.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.05
TPSA
41.49
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
MOA
Histamine Receptor
antihistamine
Indication
itching
Target
AChR,Histamine Receptor
Cholinergic
Histamine relase
H1 receptor
Source data
