General
Preferred name
METHYL SALICYLATE
Synonyms
Sodium methylsalicylate ()
Gaultheria oil ()
Methyl 2-hydroxybenzoate ()
2-Carbomethoxyphenol ()
Betula oil ()
Natural wintergreen oil ()
Wintergreen oil ()
Salicylic Acid Methyl Ester ()
2-Carbomethoxyphenol, Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil ()
Methyl salicylate component of salonpas ()
P.R. ()
FEMA NO. 2745 ()
Radian-B ()
Gppe Lin ()
Sloans ()
Fema no. 2154 ()
Dubam ()
Deep Heat ()
Luma ()
Aspellin ()
Rhodiaflor ()
Nasciodine ()
Gppe Rub ()
Bengue's Balsam ()
Thera-gesic ()
NSC-8204 ()
Flavor,wintergreen ()
Fema no. 3113 ()
Balmosa ()
Methyl salicylate,synthetic ()
Methyl Salicylate-d4 ()
P&D ID
PD013472
CAS
119-36-8
1219802-12-6
Tags
available
drug
Approved by
FDA
First approval
2008
Drug indication
Discovery agent
Myalgia
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Methyl salicylate relieve musculoskeletal pain in the muscles, joints, and tendons by causing irritation and reddening of the skin due to dilated capillaries and increased blood flow. It is pharmacologically similar to aspirin and other NSAIDs but as a topical agent it primarily acts as a rubefacient and skin irritant. It reversibly inhibits cyclooxygenase enzyme and locally and peripherally prevents the production of inflammatory mediators such as prostaglandin and thromboxane A2. Ointments or liniments containing methyl salicylate are applied topically as counter irritant for relief of acute pain associated with lumbago, sciatica and rheumatic conditions. It is used as a local analgesic for human and veterinary medicine. (Enamine Bioactive Compounds)
DESCRIPTION Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments. (TargetMol Bioactive Compound Library)
Compound Sets
18
Cayman Chemical Bioactives
42145
ChEMBL Approved Drugs
CHEMBL108545
ChEMBL Drugs
CHEMBL108545
Drug Repurposing Hub
DrugBank
DB09543
DrugBank Approved Drugs
DB09543
DrugCentral
4245
DrugCentral Approved Drugs
4245
DrugMAP
DMKCG8H
DrugMatrix
Enamine Bioactive Compounds
EBC-12859
Enamine BioReference Compounds
Guide to Pharmacology
2431
MedChem Express Bioactive Compound Library
HY-Y0189
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
methyl-salicylate
TargetMol Bioactive Compound Library
T0399
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
152.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.18
TPSA
46.53
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
COX
TRPV1
TRP Channel
MOA
TRP/TRPV Channel
Indication
fever, pain relief
Disease Area
endocrinology, neurology/psychiatry
Pathway
Immunology/Inflammation
Membrane Transporter/Ion Channel
Neuroscience
Source data