General
Preferred name
ALTANSERIN
Synonyms
Altanserin hydrochloride ()
[18F]altanserin ()
ALTANSERIN TARTRATE ()
[18F]altanserin ()
R-53,200 ()
R-53200 ()
P&D ID
PD013460
CAS
1135280-78-2
76330-71-7
139418-52-3
Tags
drug candidate
natural product
available
Drug indication
Serotonin Antagonist
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective D2 and D3 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
5-HT2A receptor antagonist
(Tocriscreen Plus)
DESCRIPTION
5-HT2A receptor antagonist
(Tocriscreen Total)
DESCRIPTION
Altanserin hydrochloride is the hydrochloride salt of altanserin, which is a selective and potent 5-HT2A receptor antagonist with Ki value of 0.13 nM. It is centrally active following systemic administration in vivo. It is also a useful intermediate for organic synthesis.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMatrix
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
NPC Screening Collection
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
411.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
3.79
TPSA
58.1
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.51
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Primary Target
5-HT2A Receptors
MOA
Antagonist
serotonin receptor antagonist
Target
HTR2A
5-HT Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data
