General
Preferred name
CYCLOGUANIL
Synonyms
4,6-Diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine salt of 4,4'-methylene-bis(3-hydroxy-2-naphthoic acid) ()
CI-501 ()
Cycloguanil Embonate ()
Chloroguanide Triazine Pamoate ()
CN-14329-23A ()
PAM-MR-807-23A ()
Cycloguanil (D6 Nitrate) ()
Cycloguanil D6 ()
Chlorguanide triazine D6 Nitrate ()
Chlorguanide triazine D6 ()
Chloroguanide Triazine ()
Cycloguanil hydrochloride ()
Cycloguanil (hydrochloride) ()
CYCLOGUANIL PAMOATE ()
CHLORCYCLOGUANIL HYDROCHLORIDE ()
Malarone ()
CN-14,329-23A ()
Embonato de cicloguanil ()
Embonate de cycloguanil ()
NSC-77830 ()
Cycloguanil-d6 (hydrochloride) ()
P&D ID
PD013453
CAS
152-53-4
516-21-2
609-78-9
2712364-69-5
Tags
available
drug candidate
drug
Drug indication
Malaria
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes[1].
PRICE
33
DESCRIPTION
Cycloguanil is an antifolate compound and a metabolite of the antimalarial drug .
The INN-assigned compound is formulated with .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
The INN-assigned compound is formulated with .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
DESCRIPTION
Cycloguanil is an antifolate compound and a metabolite of the antimalarial drug .
The INN-assigned compound is formulated with . (GtoPdb)
The INN-assigned compound is formulated with . (GtoPdb)
DESCRIPTION
Cycloguanil hydrochloride is an inhibitor of plasmodium falciparum dihydrofolate reductase.
(Enamine Bioactive Compounds)
DESCRIPTION
Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Cycloguanil is a dihydrofolate reductase inhibitor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
7
Compound Sets
19
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
251.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.53
TPSA
80.0
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antifolate
Drug Metabolite
Parasite
Pathway
Cell Cycle/DNA Damage
Metabolism
Microbiology/virology
Anti-infection
Metabolic Enzyme/Protease
Source data
