General
Preferred name
CYCLOGUANIL
Synonyms
4,6-Diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine salt of 4,4'-methylene-bis(3-hydroxy-2-naphthoic acid) ()
CI-501 ()
Cycloguanil Embonate ()
Chloroguanide Triazine Pamoate ()
CN-14329-23A ()
PAM-MR-807-23A ()
Cycloguanil (D6 Nitrate) ()
Cycloguanil D6 ()
Chlorguanide triazine D6 Nitrate ()
Chlorguanide triazine D6 ()
Chloroguanide Triazine ()
Cycloguanil hydrochloride ()
Cycloguanil (hydrochloride) ()
GNF-Pf-2519 ()
CHLORCYCLOGUANIL HYDROCHLORIDE ()
Malarone ()
TCMDC-125837 ()
CYCLOGUANIL PAMOATE ()
Embonato de cicloguanil ()
Embonate de cycloguanil ()
CN-14,329-23A ()
NSC-77830 ()
Cycloguanil-d6 (hydrochloride) ()
P&D ID
PD013453
CAS
152-53-4
516-21-2
609-78-9
2712364-69-5
Tags
available
drug candidate
drug
Drug indication
Antimalarial
Malaria
Drug Status
approved
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cycloguanil is an antifolate compound and a metabolite of the antimalarial drug .
The INN-assigned compound is formulated with .

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
DESCRIPTION Cycloguanil is an antifolate compound and a metabolite of the antimalarial drug .
The INN-assigned compound is formulated with . (GtoPdb)
DESCRIPTION Cycloguanil is a dihydrofolate reductase inhibitor. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
7
Compound Sets
18
BOC Sciences Bioactive Compounds
cycloguanil-cas-516-21-2-item-469516
Cayman Chemical Bioactives
16861
31496
ChEMBL Drugs
CHEMBL747
CHEMBL3989825
DrugBank
DB14763
DrugBank Approved Drugs
DB14763
DrugCentral
754
DrugCentral Approved Drugs
754
DrugMAP
DMC520D
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
10027
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL747
MedChem Express Bioactive Compound Library
HY-12784A
NPC Screening Collection
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
cycloguanil-hydrochloride
TargetMol Bioactive Compound Library
T5420
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
251.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.53
TPSA
80.0
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antifolate
Parasite
Drug Metabolite
Pathway
Cell Cycle/DNA Damage
Microbiology&virology
Anti-infection
Metabolic Enzyme/Protease
Source data