General
Preferred name
TRANYLCYPROMINE
Synonyms
Tranylcypromine hydrochloride ()
2-PCPA ()
TRANYLCYPROMINE SULFATE ()
Tranylcypromine (hemisulfate) ()
Tranylcypromine (2-PCPA) HCl ()
SKF-385 HCl ()
(1R,2S)-(+)-tranylcypromine ()
SKF 385 (hemisulfate) ()
Parnate ()
Tranylcipromine ()
Tranylcypromine (2-PCPA) hydrochloride ()
Tranylcypromine hemisulfate ()
(1R,2S)-2-Phenylcyclopropanaminium ()
(1R,2S)-Tranylcypromine hydrochloride ()
rac Tranylcypromine-[d5] hydrochloride ()
P&D ID
PD013449
CAS
1986-47-6
95-62-5
155-09-9
3721-26-4
13492-01-8
37388-05-9
107077-98-5
Tags
available
obsolete probe
drug
drug candidate
Approved by
FDA
First approval
1961
Drug indication
Major depressive disorder
Prostate cancer
Drug Status
approved
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
PRICE
29
DESCRIPTION
Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects[1][2].
DESCRIPTION
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Tranylcypromine, an amphetamine derivative, has been found to be a MAO inhibitor that could be used an antidepressant agent and anxiolytic drug.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Topoisomerase II inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Irreversible inhibitor of LSD1; also inhibits MAO
(Tocriscreen Plus)
DESCRIPTION
Irreversible inhibitor of MAO-A, MAO-B and LSD1
(Tocriscreen Total)
DESCRIPTION
Tranylcypromine is a monoamine oxidase inhibitor used to treat major depressive disorder.
(Enamine Bioactive Compounds)
DESCRIPTION
Tranylcypromine hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 and monoamine oxidase.
(Enamine Bioactive Compounds)
DESCRIPTION
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression.
(TargetMol Bioactive Compound Library)
DESCRIPTION
rac Tranylcypromine-[d5] hydrochloride is the labelled analogue of Tranylcypromine, which has been found to be a monoamine oxidase inhibitor and could be used as an anti-depressant agent.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
19
BOC Sciences Bioactive Compounds
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
LINCS compound set
MedChem Express Bioactive Compound Library
NPC Screening Collection
Obsolete Compounds
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
68
Molecular Weight
133.09
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
1.5
TPSA
26.02
Fraction CSP3
0.33
Chiral centers
2.0
Largest ring
6.0
QED
0.62
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
LSD1
MAO
Histone Demethylase
Monoamine Oxidase
Pathway
Chromatin/Epigenetic
Metabolism
Neuroscience
Epigenetics
Neuronal Signaling
Primary Target
Histone Demethylases
MOA
Inhibitor
Therapeutic Class
Antidepressants
Source data
