General
Preferred name
TC-S 7009
Synonyms
N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine ()
HIF-2 inhibitor 2 ()
HIF-2? Antagonist 2 ()
P&D ID
PD013371
CAS
1422955-31-4
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
3
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
High affinity and selective HIF-2alpha inhibitor
(Tocriscreen Plus)
DESCRIPTION
IAP and XIAP inhibitor; antitumor
(Tocris Bioactive Compound Library)
DESCRIPTION
TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM) that displays >60-fold selectivity for HIF-2α over HIF-1α. TC-S 7009 binds to the HIF-2α PAS-B domain to disrupt HIF-2α-ARNT heterodimerization, decrease HIF-2α DNA-binding and suppress expression of HIF-2α target genes in vitro.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
Nature Chemical Biology Probes
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
308.01
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
3.67
TPSA
94.09
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Primary Target
Hypoxia Inducible Factors (HIF)
MOA
Inhibitor
HIF-2
HIF-2 Inhibitor
hypoxia inducible factor inhibitor
Member status
member
Target
EPAS1
HIF-2 inhibitor
HIF/HIF Prolyl-Hydroxylase
HIF
Pathway
Metabolic Enzyme/Protease
Source data
