General
Preferred name
HLY78
Synonyms
4-ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine ()
P&D ID
PD013368
CAS
854847-61-3
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/¦Â-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3].
PRICE
83
DESCRIPTION
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/??-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.
DESCRIPTION
HLY78 is an activator of the Wnt/β-catenin pathway. It targets the DIX domain of Axin and potentiates the Axin-LRP6 association, thus promoting LRP6 phosphorylation and Wnt signaling transduction. In zebrafish embryos, HLY78 was shown to increase the expression of the conserved hematopoietic stem cell (HSC) markers, runx1 and cmyb.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Nature Chemical Biology Probes
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
12
Molecular Weight
267.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
2
cLogP
3.59
TPSA
21.7
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Wnt/β-catenin
Apoptosis
Wnt
β-catenin
Apoptosis related
¦Â-catenin
Member status
member
MOA
"AXIN auto-inhibition inhibitor
Wnt pathway activator"
AXIN auto-inhibition inhibitor
Wnt pathway activator
Pathway
Stem Cell/Wnt
Cytoskeletal Signaling
Stem Cells
Source data
