General
Preferred name
ADIPHENINE
Synonyms
ADIPHENINE HYDROCHLORIDE ()
Adiphenine HCl ()
Spasnil ()
Patrovina ()
Sentiv ()
Adiphenine (hydrochloride) ()
NSC 129224 ()
NSC-129224 ()
Trasentine ()
Adifenina ()
P&D ID
PD013363
CAS
50-42-0
64-95-9
Tags
available
drug
drug candidate
Drug Status
approved
investigational
withdrawn
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 ¦ÌM for ¦Á1, ¦Á3¦Â4, ¦Á4¦Â2, and ¦Á4¦Â4, respectively. Adiphenine hydrochloride has anticonvulsant effects[1][2][3].
PRICE
29
DESCRIPTION
Adiphenine hydrochloride (Patrovina), a nicotinic receptor inhibitor, can be used as an antispasmodic drug.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
16
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
311.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
3.7
TPSA
29.54
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
nAChR
Nicotinic Receptor
CHRNA1
AChR
Indication
spasms
MOA
acetylcholine receptor antagonist
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data
