General
Preferred name
THIOPERAMIDE
Synonyms
THIOPERAMIDE MALEATE ()
Thioperamide (maleate) ()
P&D ID
PD013339
CAS
106243-16-7
148440-81-7
Tags
drug candidate
natural product
available
Drug indication
Cognitive impairment
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective H3 histamine receptor antagonist that crosses the blood brain barrier
(LOPAC library)
DESCRIPTION
H3 antagonist and H4 inverse agonist
(Tocriscreen Plus)
DESCRIPTION
H1/ H2 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
H3 antagonist and H4 inverse agonist
(Tocriscreen Total)
DESCRIPTION
Thioperamide is a potent histamine H3 and H4 antagonist/inverse agonist (Ki = 25 and 27 nM for human recombinant H3 and H4 receptors, respectively). Thioperamide can cross the blood-brain barrier freely.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Thioperamide maleate is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
17
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
292.17
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
2.8
TPSA
43.95
Fraction CSP3
0.73
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
H3
Primary Target
Histamine H3 Receptors
MOA
Antagonist
Histamine H3 Receptor Inverse Agonists
Histamine H3 Receptor Antagonists
Member status
member
Source data
