General
Preferred name
OPIPRAMOL
Synonyms
Opipramol dihydrochloride ()
OPIPRAMOL HYDROCHLORIDE ()
Ensidon ()
G-33040 ()
Opipramol dura ()
NSC-169867 ()
Opipramol hcl ()
Insidon ()
P&D ID
PD013337
CAS
315-72-0
909-39-7
Tags
available
drug candidate
drug
Drug indication
Anxiety disorder
Antipsychotic
Antidepressant
Drug Status
investigational
approved
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Opipramol is an atypical tricyclic antidepressant (TCA) . It acts primarily as a sigma (σ) receptor agonist. Weak antiviral activity of opipramol dihydrochloride against SARS-CoV-2 (in Vero E6 cells; EC50 5 μM) was reported by Touret et al. . (GtoPdb)
DESCRIPTION sigma1, sigma2 receptor agonist; an antagonist at D2, 5HT2, and H1 receptors; atypical antidepressant, antipsychotic, and axiolytic. (LOPAC library)
Cell lines
0
Organisms
2
Compound Sets
15
Cayman Chemical Bioactives
29471
ChEMBL Drugs
CHEMBL370753
CHEMBL1524185
Drug Repurposing Hub
DrugBank
DB12930
DrugCentral
1993
DrugCentral Approved Drugs
1993
DrugMAP
DMPUOXF
DrugMAP Approved Drugs
DMPUOXF
DrugMatrix
Guide to Pharmacology
11247
LOPAC library
MedChem Express Bioactive Compound Library
HY-118901
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
External IDs
50
Properties
(calculated by RDKit )
Molecular Weight
363.23
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
2
cLogP
3.31
TPSA
29.95
Fraction CSP3
0.39
Chiral centers
0.0
Largest ring
7.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
1, 2
Indication
generalized anxiety disorder (GAD)
MOA
Sigma Receptor agonist
Pathway
Neuronal Signaling
Target
Sigma Receptor
Source data