General
Preferred name
SEROTONIN
Synonyms
SEROTONIN HYDROCHLORIDE ()
5-Hydroxy Tryptamine ()
5-hydroxytryptamine ()
5-HT ()
5-HT hydrochloride ()
5-HT HCl ()
Serotonin HCl ()
5-Hydroxytryptamine hydrochloride ()
[3H]5-HT ()
Serotonin (hydrochloride) ()
Thrombotonin ()
Enteramine ()
5-ht ()
[3H]5-HT ()
Serotonin-d4 (hydrochloride) ()
Serotonin (hydrochloride) ()
P&D ID
PD013329
CAS
153-98-0
1094000-36-8
50-67-9
2469263-61-2
Tags
available
drug candidate
Drug indication
Discovery agent
Chemotherapy-induced nausea and vomiting
Drug Status
investigational
nutraceutical
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 ??M).
PRICE 115
DESCRIPTION Endogenous neurotransmitter (LOPAC library)
DESCRIPTION Endogenous 5-HT receptor agonist (Tocriscreen Total)
DESCRIPTION Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. It is a neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite. (Enamine Bioactive Compounds)
DESCRIPTION Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). (TargetMol Bioactive Compound Library)
DESCRIPTION Serotonin (5-hydroxytryptamine) is a natural product from animals (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
3
Compound Sets
27
Cayman Chemical Bioactives
14332
33680
29415
ChEMBL Drugs
CHEMBL39
Concise Guide to Pharmacology 2017/18
5
3248
Concise Guide to Pharmacology 2019/20
5
3248
Concise Guide to Pharmacology 2021/22
5
3248
Concise Guide to Pharmacology 2023/24
5
3248
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB08839
DrugMAP
DMOFCRY
DMYJXV7
DrugMatrix
Enamine Bioactive Compounds
EBC-13726
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101049
EUbOPEN Chemogenomics Library
EUB0000897
Guide to Pharmacology
5
3248
Ki Database
5-Hydroxy Tryptamine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL39
Mcule NIBR MoA Box Subset
MCULE-8788459983
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
serotonin-hcl
TargetMol Bioactive Compound Library
T2209
TN2437
The Spectrum Collection
Tocriscreen Total
External IDs
69
Properties
(calculated by RDKit )
Molecular Weight
176.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.37
TPSA
62.04
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
COMT
Endogenous Metabolite
5-HT
DRD1, DRD5, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, HTR7, SLC36A1
Member status
member
MOA
serotonin receptor agonist
growth factor receptor activator
Indication
anxiety, depression, sleeplessness
Pathway
GPCR/G protein
Metabolism
Neuroscience
Recommended Cell Concentration
10 nM
Source data