General
Preferred name
AMOROLFINE
Synonyms
AMOROLFINE HYDROCHLORIDE ()
Ro-14-4767 ()
Amorolfine HCl ()
Ro 14-4767/002 ()
Amorolfin ()
Amorolfine (hydrochloride) ()
Ro 14-4767 HCl ()
Amorolfine (as hydrochloride) ()
Amorolfina ()
RO-14-4767/000 ()
RO 14-4767/000 ()
Loceryl Curanail ()
Omicur ()
Loceryl ()
P&D ID
PD013326
CAS
78613-38-4
67467-83-8
78613-35-1
Tags
available
drug
Drug Status
approved
investigational
Max Phase
3.0
Drug indication
tinea unguium
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis[1][2].
DESCRIPTION
Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine hydrochloride , a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Pandemic Response Box
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
317.27
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
4.66
TPSA
12.47
Fraction CSP3
0.71
Chiral centers
3.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology/virology
Microbiology&virology
Anti-infection
MOA
Antibiotic
Target
antibiotic
Fungal
Source data
