General
Preferred name
CANRENONE
Synonyms
SC14266 ()
SC9376 ()
Aldadiene ()
RP-11614 ()
6,7-Dehydro-7??-desthioacetylspironolactone ()
Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone ()
6,7-Dehydro-7¦Á-desthioacetylspironolactone ()
Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7??-desthioacetylspironolactone ()
Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7¦Á-desthioacetylspironolactone ()
Spironolactone related compound a ()
SC-9376 ()
Spironolactone metabolite m1 ()
NSC-261713 ()
Canrenone ()
P&D ID
PD013317
CAS
154738-42-8
976-71-6
Tags
natural product
drug
available
Drug Status
investigational
approved
withdrawn
Max Phase
Phase 4
Drug indication
Aldosterone Antagonist
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
Enamine BioReference Compounds
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
340.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
0
cLogP
4.37
TPSA
43.37
Fraction CSP3
0.73
Chiral centers
6.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Target
Mineralocorticoid Receptor
NR3C2
Endogenous Metabolite
Member status
member
MOA
Mineralocorticoid Receptor (MR) Antagonists
Mineralocorticoid Receptor Antagonist
ATC
C03DA03
Toxicity type
carcinogenicity
Source data
