General
Preferred name
CANRENONE
Synonyms
Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7α-desthioacetylspironolactone ()
6,7-Dehydro-7¦Á-desthioacetylspironolactone ()
Aldadiene ()
SC9376 ()
Aldadiene, SC-9376, RP-11614, 6,7-Dehydro-7¦Á-desthioacetylspironolactone ()
Canrenone ()
SC-9376 ()
Spironolactone metabolite m1 ()
NSC-261713 ()
Canrenona ()
Spironolactone related compound a ()
P&D ID
PD013317
CAS
154738-42-8
976-71-6
Tags
available
drug
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
Cardiovascular disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.
PRICE
29
DESCRIPTION
Canrenone (SC14266) is an aldosterone antagonist with potassium-sparing diuretic activity.
DESCRIPTION
Canrenone, a spironolactone metabolite, is a mineralocorticoid receptor antagonist, IC50= 300nM in COS-7 cell line.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
340.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
0
cLogP
4.37
TPSA
43.37
Fraction CSP3
0.73
Chiral centers
6.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Mineralocorticoid Receptor (MR) Antagonists
Mineralocorticoid Receptor Antagonist
Target
NR3C2
Endogenous Metabolite
Mineralocorticoid Receptor
ATC
C03DA03
Toxicity type
carcinogenicity
Pathway
Metabolic Enzyme/Protease
Vitamin D Related/Nuclear Receptor
Source data
