General
Preferred name
OXOLAMINE
Synonyms
OXOLAMINE CITRATE ()
Oxobron ()
AF-438 citrate ()
SKF-9976 citrate ()
Oxalamine citrate salt ()
Oxolamine citrate salt ()
Oxolamine (citrate) ()
SKF-9976 citrate, AF-438 citrate ()
SKF 9976 FREE BASE ()
SKF-9976 FREE BASE ()
Oxolamina ()
AF-438 FREE BASE ()
Oksalamin ()
P&D ID
PD013313
CAS
959-14-8
34155-96-9
1949-20-8
Tags
available
drug
Drug Status
approved
withdrawn
investigational
Max Phase
3.0
Drug indication
Cough
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Oxolamine citrate (SKF-9976 citrate) is an orally active antitussive. Oxolamine citrate can inhibit CYP2B1/2. Oxolamine citrate has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine citrate increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine citrate can be used in respiratory disease research[1][2][3][4].
DESCRIPTION
Oxolamine citrate (AF-438 citrate) is a cough suppressant that is able to be used as a generic drug in many jurisdictions.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
245.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.62
TPSA
42.16
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
cough suppressant
MOA
antitussive
ATC
R05DB07
Toxicity type
neurological
Target
Cytochrome P450
P450 (e.g. CYP17)
Pathway
Metabolic Enzyme/Protease
Source data
