General
Preferred name
PROADIFEN
Synonyms
PROADIFEN HYDROCHLORIDE ()
Sk525 ()
SKF-525A hydrochloride ()
RP-5171 ()
U-5446 ()
SKF-525A ()
Proadifen (hydrochloride) ()
Proadifen HCl ()
SKF 525-A HCl ()
NSC-170997 ()
SK&F 525-A ()
RP 5171 ()
SKF 525A (hydrochloride) ()
P&D ID
PD013312
CAS
62-68-0
302-33-0
Tags
drug candidate
natural product
available
Drug indication
Synergist (non-specific)
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibitor of microsomal drug metabolism
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
11
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugMatrix
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
51
Molecular Weight
353.24
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
2
cLogP
4.66
TPSA
29.54
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Microsomal oxidation
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
CYP
NOS1
Cytochrome P450
CYP450
Member status
member
MOA
Neuronal Nitric Oxide Synthase Inhibitors
Cytochrome P450 Inhibitors
Potassium Channel Blockers
nitric oxide synthase inhibitor
Source data
