General
Preferred name
DEXAMETHASONE ACETATE
Synonyms
BETAMETHASONE ACETATE ()
Hexadecadrol (acetate) ()
Dexamethasone 21-acetate ()
Dexamethasone 17-acetate ()
Dexamethason acetate ()
NSC 39471 ()
Hexadecadrol acetate ()
NSC 39471,Dexamethasone 21-acetate ()
Dexamethasone acetate anhydrous ()
Dexamethasoni acetas monohydrate ()
Dectancyl ()
Dexamethasoni acetas ()
Fortecortin (crystal suspension) ()
Neofordex ()
Dexamethasone acetate monohydrate ()
NSC-39471 ()
Decadron-LA ()
P&D ID
PD013304
CAS
1177-87-3
Tags
available
drug
Approved by
FDA
First approval
1973
Drug Status
vet_approved
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
Leukemia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Dexamethasone acetate (Dexamethasone 21-acetate) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
DESCRIPTION Dexamethasone acetate is a glucocorticosteroid used for the treatment of inflammatory respiratory, allergic, autoimmune, and other conditions. (Enamine Bioactive Compounds)
DESCRIPTION Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (TargetMol Bioactive Compound Library)
Compound Sets
15
Cayman Chemical Bioactives
22286
ChEMBL Approved Drugs
CHEMBL1530428
ChEMBL Drugs
CHEMBL1530428
Drug Repurposing Hub
DrugBank
DB14649
DrugBank Approved Drugs
DB14649
DrugCentral
826
DrugCentral Approved Drugs
826
Enamine Bioactive Compounds
EBC-17107
MedChem Express Bioactive Compound Library
HY-14648A
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
dexamethasone-acetate
TargetMol Bioactive Compound Library
T0947
Withdrawn 2.0
245
External IDs
34
Properties
(calculated by RDKit )
Molecular Weight
434.21
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
0
cLogP
2.47
TPSA
100.9
Fraction CSP3
0.71
Chiral centers
8.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Autophagy
Endocrinology/Hormones
GPCR/G protein
Immunology/Inflammation
Microbiology/virology
Antibody-drug Conjugate/ADC Related
Anti-infection
Vitamin D Related/Nuclear Receptor
Disease Area
endocrinology, rheumatology, allergy, gastroenterology, hematology, neurology/psychiatry, dermatology
Indication
hypercalcemia, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, allergic rhinitis, ulcerative colitis, anemia, multiple sclerosis, enteritis, lupus, dermatitis herpetiformis (DH), nephrotic syndrome, psoriasis
MOA
Glucocorticoid Receptor agonist
ATC
A01AC02
C05AA09
D07AB19
D07XB05
D10AA03
H02AB02
R01AD03
S01BA01
S01CB01
S02BA06
S03BA01
Target
ADC Payload
antibiotic
Bacterial
Complement System
Glucocorticoid Receptor
Mitophagy
SARS-CoV
Complement System,COVID-19,IL Receptor
ADC Cytotoxin
Annexin A1
IL Receptor
Inos
Source data