General
Preferred name
DILAZEP
Synonyms
Dilazep hydrochloride ()
Dilazep dihydrochloride ()
Dilazep (dihydrochloride) ()
Dilazep (hydrochloride) ()
P&D ID
PD013300
CAS
20153-98-4
35898-87-4
Tags
natural product
drug
available
Drug indication
Discovery agent
Drug Status
experimental
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dilazep is a equilibrative nucleoside transporter 1 (ENT1) inhibitor. The crystal structure of human ENT1 in complex with dilazep is deposited in the Protein Data Bank under accession code 6OB7 .
(GtoPdb)
DESCRIPTION
Adenosine uptake inhibitor
(LOPAC library)
DESCRIPTION
Adenosine uptake inhibitor
(Tocriscreen Total)
DESCRIPTION
The hydrochloride salt form of Dilazep, which has been found to be an angiotensin converting, adenosine reuptake inhibitor and could be used as a cerebral vasodialator.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Potent and selective DA uptake inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
23
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMatrix
Guide to Pharmacology
JUMP-Target 1 Compound Set
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
604.3
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
0
Rotatable Bonds
16
Ring Count
3
Aromatic Ring Count
2
cLogP
3.54
TPSA
114.46
Fraction CSP3
0.55
Chiral centers
0.0
Largest ring
7.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Primary Target
Nucleoside Transporters
MOA
Inhibitor
Adenosine Reuptake Inhibitor
Member status
member
Indication
coronary heart disease
Target
SLC29A1
Source data
