General
Preferred name
CLOFILIUM
Synonyms
Clofilium phosphate ()
Clofilium tosylate ()
Clofilium cation ()
Clofilium ion ()
LY-150378 ()
Fosfato de clofilio ()
Phosphate de clofilium ()
LY 150378 ()
P&D ID
PD013296
CAS
92953-10-1
68379-02-2
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent[1].
PRICE
81
DESCRIPTION
Clofilium tosylate is a potassium channel blocker, induces apoptosis on human promyelocytic leukemia (HL-60) cells.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
9
ChEMBL Drugs
Drug Repurposing Hub
DrugMAP
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
42
Molecular Weight
338.26
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
13
Ring Count
1
Aromatic Ring Count
1
cLogP
6.49
TPSA
0.0
Fraction CSP3
0.71
Chiral centers
0.0
Largest ring
6.0
QED
0.28
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Potassium Channel
KCNA5, KCNH1
Apoptosis
MOA
potassium channel blocker
Pathway
Membrane Transporter/Ion Channel
Source data
