General
Preferred name
(-)-propranolol
Synonyms
PROPRANOLOL HYDROCHLORIDE [S(-)] ()
(S)-PROPRANOLOL HYDROCHLORIDE ()
(S)-(-)-Propranolol hydrochloride ()
(R)-Propranolol hydrochloride ()
S(-)-Propranolol HCl ()
(S)-(-)-Propranolol (hydrochloride) ()
Hemangeol, Inderal ()
S(-)-Propranolol hydrochloride ()
LEVOPROPRANOLOL ()
Propanolol ()
P&D ID
PD013280
CAS
4199-10-4
4199-09-1
13071-11-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(S)-(-)-Propranolol hydrochloride is a ¦Â-adrenergic receptor antagonist with log Kd?values of -8.16, -9.08, and -6.93 for ¦Â1, ¦Â2, and ¦Â3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[2].
PRICE
29
DESCRIPTION
A component of the approved drug propranolol. Propranolol is a racemic mixture of two enantiomers (+)-propranolol, and (-)-propranolol. Some of the database entries linked to from this page may refer to the mixture and do not specify stereochemistry in the images of the structue shown.
(GtoPdb)
DESCRIPTION
Active beta-adrenoceptor receptor blocking enantiomer; 5-HT1 serotonin receptor antagonist
(LOPAC library)
DESCRIPTION
β antagonist. More active enantiomer of propranolol (Cat. No. 0624)
(Tocriscreen Total)
DESCRIPTION
beta antagonist. Less active enantiomer of propranolol (Cat. No. 0624)
(Tocris Bioactive Compound Library)
DESCRIPTION
(S)-(-)-Propranolol hydrochloride, an adrenergic receptor antagonist, exhibits potential anticancer activity and may enhance the prognosis of burn patients.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
16
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
41
Molecular Weight
259.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.58
TPSA
41.49
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta
Target
β-adrenergic receptor
ADRB1, HTR1A, HTR5A, SLC10A1
Adrenergic Receptor
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Antagonist
Adrenergic Receptor antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data
