General
Preferred name
AH5183
Synonyms
(±)-Vesamicol hydrochloride ()
(+/-)-Vesamicol hydrochloride ()
L(-)-vesamicol hydrochloride ()
(-)-Vesamicol ()
(±)-Vesamicol (hydrochloride) ()
(±)-AH5183 (hydrochloride) ()
(¡À)-Vesamicol (hydrochloride) ()
vesamicol ()
(¡À)-AH5183 (hydrochloride) ()
P&D ID
PD013275
CAS
112709-59-8
115362-28-2
120447-62-3
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(¡À)-Vesamicol hydrochloride ((¡À)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (¡À)-Vesamicol hydrochloride also displays high affinity for ¦Ò1 and ¦Ò2 receptors with Kis of 26 nM and 34 nM, respectively[1][2].
DESCRIPTION
(-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC50 of 75 nM[1]. (-)-Vesamicol can be used for release and recycling of synaptic vesicles study[1].
DESCRIPTION
Potent, specific ligand for mitochondrial DBI receptor
(Tocris Bioactive Compound Library)
DESCRIPTION
Inhibits ACh transport
(Tocriscreen Plus)
DESCRIPTION
Inhibits ACh transport
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
Drug Repurposing Hub
Mcule NIBR MoA Box Subset
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
259.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
3.17
TPSA
23.47
Fraction CSP3
0.65
Chiral centers
2.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
mAChR
SLC18A3
Sigma Receptor
Target Type
Transporters
Primary Target
Acetylcholine Transporters
MOA
Inhibitor
Acetylcholinesterase inhibitor
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Source data
