General
Preferred name
URAPIDIL
Synonyms
URAPIDIL HYDROCHLORIDE ()
Mediatensyl ()
Ebrantil ()
Eupressyl ()
Urapidil HCl ()
Urapidil (hydrochloride) ()
NSC-310405 ()
Urapidil-d3 ()
P&D ID
PD013272
CAS
34661-75-1
64887-14-5
102411-11-0
1398066-08-4
Tags
available
drug candidate
drug
First approval
1981
Drug indication
Aortic dissection
Hypertension
Inflammation
Drug Status
approved
investigational
Max Phase
3.0
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Urapidil hydrochloride is an orally active ¦Á1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against ¦Á1- and ¦Á2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect[1][2].
DESCRIPTION Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an ??1-adrenoceptor antagonist.
DESCRIPTION Urapidil is a piperazine compound. It has activity as an α1-adrenoceptor antagonist and as a 5-HT1A receptor agonist . (GtoPdb)
PRICE 29
DESCRIPTION Urapidil is an ¦Á1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.
DESCRIPTION Urapidil (Ebrantil), a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an ??1-adrenoceptor antagonist.
DESCRIPTION alpha1 Adrenoceptor antagonist and 5-HT1A serotonin receptor partial agonist; antihypertensive (LOPAC library)
DESCRIPTION α1 antagonist. Also 5-HT1A receptor agonist (Tocriscreen Total)
DESCRIPTION Urapidil HCl is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. (TargetMol Bioactive Compound Library)
DESCRIPTION Urapidil (Ebrantil), a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
25
AdooQ Bioactive Compound Library
A11704
BOC Sciences Bioactive Compounds
urapidil-hcl-cas-64887-14-5-item-84-74431
Cayman Chemical Bioactives
29004
43811
ChEMBL Drugs
CHEMBL1256716
CHEMBL279229
Drug Repurposing Hub
DrugBank
DB12661
DrugCentral
2796
DrugCentral Approved Drugs
2796
DrugMAP
DMD59GI
DrugMAP Approved Drugs
DMD59GI
DrugMatrix
Guide to Pharmacology
13357
Ki Database
URAPIDIL
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-3938625225
MedChem Express Bioactive Compound Library
HY-B0354A
HY-B0716
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
urapidil-hydrochloride
urapidil
TargetMol Bioactive Compound Library
T0088
T0165
The Spectrum Collection
Tocriscreen Total
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
387.23
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
0.72
TPSA
71.74
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha1
Target
5-HT
5-HT Receptor
Adrenergic Receptor
α1-adrenergic receptor
α-adrenergic receptor
¦Á-adrenergic receptor
¦Á1-adrenergic receptor
HTR1A
5-HT Receptor,Adrenergic Receptor
MOA
5-HT Receptor antagonist
alpha1-Adrenoceptor Antagonists
Adrenergic Receptor antagonist
Member status
member
Indication
hypertension
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data