General
Preferred name
CYCLOPENTHIAZIDE
Synonyms
Cyclomethiazide ()
Su-8341 ()
SU 8341 ()
NSC-107679 ()
Navidrex ()
Ciclopentiazida ()
P&D ID
PD013265
CAS
742-20-1
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Drug indication
Cardiovascular disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cyclopenthiazide is a benzothiadiazine diuretic with antihypertensive properties. Cyclopenthiazide exerts a diuretic effect by inhibiting the reabsorption of sodium chloride and water at the distal renal tubules. Cyclopenthiazide increases the excretory capacity of the rat kidney[1].
PRICE 29
DESCRIPTION The drug used as cyclopenthiazide is a racemic mixture of (R)- and (S)-stereoisomers (PubChem CIDs 6604279 and 40463616 respectively). (GtoPdb)
DESCRIPTION Cyclopenthiazide (Cyclomethiazide) is a thiazide diuretic used to treat hypertension and heart failure. It decreases the excretion of calcium ions and uric acid and increases the excretion of sodium and potassium ions. (TargetMol Bioactive Compound Library)
Compound Sets
12
ChEMBL Drugs
CHEMBL1373254
DrugBank
DB13532
DrugBank Approved Drugs
DB13532
DrugCentral
756
DrugCentral Approved Drugs
756
DrugMatrix
Guide to Pharmacology
7899
MedChem Express Bioactive Compound Library
HY-109542
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T21469
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
379.04
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
1.6
TPSA
118.36
Fraction CSP3
0.54
Chiral centers
1.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data