General
Preferred name
DROFENINE
Synonyms
DROFENINE HYDROCHLORIDE ()
Hexahydroadiphenine hydrochloride ()
Drofenine (hydrochloride) ()
Drofenina ()
NSC-757809 ()
Cycloadiphenine ()
P&D ID
PD013257
CAS
1679-76-1
3146-20-1
3146-19-8
548-66-3
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Drofenine (Cycloadiphene) hydrochloride is a potent competitive cholinesterase inhibitor with a Ki value of 3 ¦ÌM[1].
DESCRIPTION
Drofenine hydrochloride (Hexahydroadiphenine hydrochloride) is an effective competitive inhibitor of BChE (Ki value: 3 uM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
317.24
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
4.24
TPSA
29.54
Fraction CSP3
0.65
Chiral centers
1.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChE
Cholinesterase (ChE)
BChE
Pathway
Neuroscience
Neuronal Signaling
Source data
