General
Preferred name
GALLAMINE
Synonyms
GALLAMINE TRIETHIODIDE ()
Benzkurin ()
Flaxedil ()
Gallamine triethiodide (Flaxedil) ()
Gallamini triethiodidum ()
Benzcurine Iodide ()
Trietioduro de galamina ()
NSC-102690 ()
Remyolan ()
Triethiodure de gallamine ()
Gallomone Triethiodide ()
Relaxan ()
Syncurarine ()
Gallamine ()
Gallamine (iodide) ()
P&D ID
PD013256
CAS
65-29-2
7006-17-9
153-76-4
Tags
available
drug
Approved by
FDA
Drug indication
Stabilize muscle contraction
Drug Status
withdrawn
approved
Max Phase
4.0
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
The approved drug contains three iodine ions and is called gallamine triethiodide. This drug is known as a nondepolarizing neuromuscular blocking drug (NDMRD).
(GtoPdb)
DESCRIPTION
M2 muscarinic acetylcholine receptor antagonist; muscle relaxant
(LOPAC library)
DESCRIPTION
Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM. It is is a non-depolarising muscle relaxant.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Gallamine is an allosteric modulator of muscarinic acetylcholine receptors. Formulations containing gallamine have previously been used as neuromuscular blockers during surgery.
(Enamine Bioactive Compounds)
DESCRIPTION
Gallamine triethiodide (Benzkurin), a synthetic inhibiting drug, is nondepolarizing.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
33
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
510.46
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
21
Ring Count
1
Aromatic Ring Count
1
cLogP
5.45
TPSA
27.69
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
6.0
QED
0.21
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
M2
Target
AChR
mAChR
CHRM2, CHRNA1
MOA
AChR antagonist
acetylcholine receptor antagonist
Indication
muscle relaxant
ATC
M03AC02
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Therapeutic Class
Skeletal Muscle Relaxants
Source data
