General
Preferred name
DIPHEMANIL
Synonyms
DIPHEMANIL METHYLSULFATE ()
Diphemanil metilsulfate ()
Diphenmanil methylsulfate ()
Diphemanil mesylate ()
Diphemanil ()
Diphenmanil (methylsulfate) ()
Prantal ()
NSC-41725 ()
Diphemanil methylsulphate ()
Diphemanil cation ()
Diphemanil ion ()
Diphemanil (methyl sulfate) ()
P&D ID
PD013248
CAS
62-97-5
15394-62-4
Tags
available
drug
Approved by
FDA
First approval
1982
1976
Drug Status
withdrawn
approved
vet_approved
Drug indication
Peptic ulcer
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Diphemanil Methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
MOA Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body.
INDICATION Used in the treatment of peptic ulcer, gastric hyperacidity, and hypermotility in gastritis and pylorospasm, and in the treatment of hyperhidrosis (excessive perspiration).
ABSORPTION Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
Compound Sets
18
Cayman Chemical Bioactives
30090
ChEMBL Approved Drugs
CHEMBL1200880
CHEMBL1201340
ChEMBL Drugs
CHEMBL1200880
CHEMBL1201340
Drug Repurposing Hub
DrugBank
DB13720
DrugBank Approved Drugs
DB13720
DrugCentral
915
DrugCentral Approved Drugs
915
DrugMAP
DMXVU6D
DrugMAP Approved Drugs
DMXVU6D
DrugMatrix
MedChem Express Bioactive Compound Library
HY-16171
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
diphemanil-methylsulfate
TargetMol Bioactive Compound Library
T0594
Withdrawn 2.0
106
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
278.19
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
4.36
TPSA
0.0
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Target
AChR
CHRM3
mAChR
MOA
AChR antagonist
acetylcholine receptor antagonist
Indication
spasms
ATC
A03AB15
Therapeutic Class
Parasympatholytics
Source data