General
Preferred name
QUIPAZINE
Synonyms
QUIPAZINE MALEATE ()
Quipazine dimaleate ()
Quipazine dimaleate salt ()
Quipazine Dihydrochloride ()
Azaperone (dimaleate) ()
Quipazine (maleate) ()
Quipazine (dimaleate) ()
2-(piperazin-1-yl)quinoline ()
NSC-758469 ()
MA-1291 ()
MA 1291 ()
Quipazina ()
Quizapine dihydrochloride ()
QUIPAZINA ()
P&D ID
PD013226
CAS
5786-68-5
4774-24-7
150323-78-7
928026-67-9
1245646-84-7
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Quipazine maleate is a 5-HT agonist that causes behavioural changes such as hyperactivity. Quipazine maleate also shows a weak reversible MAO inhibitory activity[1].
PRICE 29
DESCRIPTION Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 ¦ÌM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research[1][2][3][4].
DESCRIPTION Quipazine belongs to the piperazine family of compounds and may act to improve function of the spinal nerve circuitry . (GtoPdb)
DESCRIPTION Quipazine is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 ¦ÌM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research[1][2][3][4].
DESCRIPTION 5-HT3 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Serotonin receptor agonist (LOPAC library)
DESCRIPTION 5-HT3 agonist (Tocriscreen Total)
DESCRIPTION Quipazine dimaleate is a slective 5-HT3 receptor agonist, and also displays antagonist activity at peripheral 5-HT3 receptors. Quipazine was shown to increase serotonin and decrease 5-hydroxyindoleacetic acid concentrations in whole brain, several brain regions, and the spinal cord of rats 1 hr after its administration (10 mg/kg, i.p.). (BOC Sciences Bioactive Compounds)
DESCRIPTION Quipazine dimaleate is a selective 5-HT3 agonist. (TargetMol Bioactive Compound Library)
DESCRIPTION Quizapine is a piperazine-based nonselective serotonin (5-HT) receptor agonist with antidepressant and oxytocic activities. (Enamine Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
26
BOC Sciences Bioactive Compounds
quipazine-dimaleate-cas-150323-78-7-item-170000
Cayman Chemical Bioactives
42262
ChEMBL Drugs
CHEMBL1256794
CHEMBL18772
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMPY6IG
DrugMatrix
Enamine Bioactive Compounds
EBC-50027
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101910
EUbOPEN Chemogenomics Library
EUB0001975
Guide to Pharmacology
173
Ki Database
QUIPAZINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL18772
Mcule NIBR MoA Box Subset
MCULE-2654170894
MedChem Express Bioactive Compound Library
HY-B1495
HY-101046
HY-W028142
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
quipazine-maleate
TargetMol Bioactive Compound Library
T23212
The Spectrum Collection
Tocris Bioactive Compound Library
0629
Tocriscreen Total
ZINC Tool Compounds
ZINC000000002020
External IDs
54
Properties
(calculated by RDKit )
Molecular Weight
213.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
1.64
TPSA
28.16
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT3
HTR1A, HTR1D, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR6, SLC6A4
5-HT Receptor
SARS-CoV
Primary Target
5-HT3 Receptors
MOA
Agonist
5-HT3 receptor agonist selective against 5-HT1B
serotonin receptor agonist
Member status
member
Pathway
Anti-infection
GPCR/G protein
Neuronal Signaling
Neuroscience
Recommended Cell Concentration
None
Source data