General
Preferred name
QUIPAZINE
Synonyms
QUIPAZINE MALEATE ()
Quipazine dimaleate ()
Quipazine dimaleate salt ()
Quipazine Dihydrochloride ()
Quipazine (dimaleate) ()
NSC-758469 ()
MA-1291 ()
MA 1291 ()
P&D ID
PD013226
CAS
5786-68-5
4774-24-7
150323-78-7
928026-67-9
1245646-84-7
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Oxytocic
Antidepressant
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Quipazine belongs to the piperazine family of compounds and may act to improve function of the spinal nerve circuitry . (GtoPdb)
DESCRIPTION 5-HT3 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Serotonin receptor agonist (LOPAC library)
DESCRIPTION 5-HT3 agonist (Tocriscreen Total)
DESCRIPTION Quipazine dimaleate is a slective 5-HT3 receptor agonist, and also displays antagonist activity at peripheral 5-HT3 receptors. Quipazine was shown to increase serotonin and decrease 5-hydroxyindoleacetic acid concentrations in whole brain, several brain regions, and the spinal cord of rats 1 hr after its administration (10 mg/kg, i.p.). (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
2
Compound Sets
21
BOC Sciences Bioactive Compounds
quipazine-dimaleate-cas-150323-78-7-item-170000
ChEMBL Drugs
CHEMBL1256794
CHEMBL18772
Drug Repurposing Hub
DrugMAP
DMPY6IG
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101910
Guide to Pharmacology
173
Ki Database
QUIPAZINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL18772
Mcule NIBR MoA Box Subset
MCULE-2654170894
MedChem Express Bioactive Compound Library
HY-101046
HY-W028142
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
quipazine-maleate
The Spectrum Collection
Tocris Bioactive Compound Library
0629
Tocriscreen Total
ZINC Tool Compounds
ZINC000000002020
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
213.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
1.64
TPSA
28.16
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
5-HT3 Receptors
MOA
Agonist
5-HT3 receptor agonist selective against 5-HT1B
serotonin receptor agonist
Member status
member
Target
HTR1A, HTR1D, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR6, SLC6A4
5-HT Receptor
SARS-CoV
Pathway
Anti-infection
GPCR/G protein
Neuronal Signaling
Source data