General
Preferred name
guanabenz
Synonyms
GUANABENZ ACETATE ()
NSC68982 ()
Wy8678 acetate ()
BR-750 ()
Wytensin ()
Guanabenz (hydrochloride) ()
Guanabenz (Acetate) ()
WY-8678 acetate ()
GBZ, GA, Wytensin, Wy-8678,BR-750 ()
Guanabenz hydrochloride ()
WY-8678 ()
NSC-757044 ()
Guanabenz monoacetate ()
NSC-68982 ()
P&D ID
PD013220
CAS
23256-50-0
34817-44-2
23113-43-1
60329-03-5
5051-62-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1982
Drug indication
Antihypertensive
High blood pressure
Drug Status
approved
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective alpha1 agonist (Tocris Bioactive Compound Library)
DESCRIPTION Centrally acting alpha2 adrenoceptor agonist; antihypertensive (LOPAC library)
DESCRIPTION α2 agonist. Also I2 selective ligand (Tocriscreen Total)
DESCRIPTION Guanabenz Acetate is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively. It is used as an antihypertensive drug. (BOC Sciences Bioactive Compounds)
DESCRIPTION Guanabenz is an agonist of α2-adrenergic receptor with hypotensive effects. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
24
AdooQ Bioactive Compound Library
A13635
Bioprocess diversity set
BOC Sciences Bioactive Compounds
guanabenz-acetate-cas-23256-50-0-367341
guanabenz-hydrochloride-cas-23113-43-1-item-74827
Cayman Chemical Bioactives
10851
ChEMBL Approved Drugs
CHEMBL1200560
CHEMBL420
ChEMBL Drugs
CHEMBL1200560
CHEMBL420
Concise Guide to Pharmacology 2017/18
5443
Concise Guide to Pharmacology 2019/20
5443
Drug Repurposing Hub
DrugCentral
3952
DrugCentral Approved Drugs
3952
DrugMAP
DM5QWEL
DrugMAP Approved Drugs
DM5QWEL
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL420
MedChem Express Bioactive Compound Library
HY-B0566
HY-12724A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
guanabenz-wy-8678-acetate
guanabenz
TargetMol Bioactive Compound Library
T6522
Tocris Bioactive Compound Library
0885
Tocriscreen Total
ZINC Tool Compounds
ZINC000000001522
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
230.01
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.81
TPSA
74.26
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha2
Biological process
Glycosylation & protein folding/targeting, cell wall biogenesis
Pathway
GPCR/G protein
Neuroscience
Anti-infection
Neuronal Signaling
Target
??2A-adrenergic receptor
??2B-adrenergic receptor
??2C-adrenergic receptor
ADRA2A, ADRA2B, ADRA2C
Adrenergic Receptor
Parasite
Primary Target
Adrenergic ?2 Receptors
MOA
Agonist
Adrenergic Receptor agonist
Indication
hypertension
Therapeutic Class
Sympatholytics
Source data