General
Preferred name
BENZAMIL
Synonyms
BENZAMIL HYDROCHLORIDE ()
Benzylamiloride hydrochloride ()
Benzamil (hydrochloride) ()
Benzamil hydrochloride hydrate ()
Benzylamiloride (hydrochloride) ()
Benzamil HCl ()
P&D ID
PD013210
CAS
2898-76-2
161804-20-2
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective GlyT1 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative
(Tocriscreen Plus)
DESCRIPTION
Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
19
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
JUMP-Target 1 Compound Set
Ki Database
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
319.09
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
0.54
TPSA
145.3
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Selectivity
Na+/H+, Na+/Ca2+ Pump
Pathway
Membrane Transporter/Ion Channel
Target
ENaC
ASIC1, PKD2L1, SCNN1A, SCNN1B, SCNN1D, SCNN1G, SLC8A1
SCNN1G
Sodium Channel
Primary Target
Na+/Ca2+ Exchanger
MOA
Inhibitor
PKD2L2 gene inhibitor
Sodium calcium exchanger 1 inhibitor
"PKD2L2 gene inhibitor
"
Sodium Channel blocker
Member status
member
Source data
