General
Preferred name
metacycline
Synonyms
METHACYCLINE HYDROCHLORIDE ()
METHACYCLINE ()
Rondomycin ()
Methacycline HCl ()
Methacycline ()
Methacycline (hydrochloride) ()
Methacycline (hydrochloride) ()
NSC-757835 ()
Metacycline hydrochloride ()
NSC-356465 ()
Metaciclina ()
GS-2876 ()
MOTC ()
P&D ID
PD013171
CAS
3963-95-9
914-00-1
Tags
available
drug
Approved by
FDA
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
bacterial disease
osteomyelitis
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methacycline hydrochloride is a tetracycline antibiotic and can inhibits bacterial protein synthesis. Methacycline hydrochloride is a potent epithelial-mesenchymal transition (EMT) inhibitor. Methacycline hydrochloride blocks EMT in vitro and fibrogenesis in vivo without directly affecting TGF-¦Â1 Smad signaling. Methacycline hydrochloride is an antimicrobial and has the potential for pulmonary fibrosis[1].
PRICE
29
DESCRIPTION
Metacycline is a tetracycline antibacterial compound, derived from . Note that the structure shown here matches the CAS-assigned structure. The PubChem link, provided in the table below, is to their standardized chemical structure (CID 54675785), although this is not an exact structural match.
(GtoPdb)
DESCRIPTION
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
16
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
442.14
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
6
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
-0.44
TPSA
181.62
Fraction CSP3
0.32
Chiral centers
5.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
16S ribosome
30S ribosome
antibiotic
Bacterial
Antibiotics
ATC
J01AA05
Pathway
Microbiology/virology
Anti-infection
Source data
