General
Preferred name
METHYLDOPATE
Synonyms
Methyldopate hydrochloride ()
Methyldopate ()
Methyldopate hcl ()
Methyldopa l-form ethyl ester hydrochloride ()
NSC-760088 ()
Aldomet ()
P&D ID
PD013169
CAS
2544-09-4
2508-79-4
6014-30-8
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1962
Drug indication
Hypertension
Antihypertensive
Drug Status
approved
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Methyldopate is an antihypertensive medication for the treatment of hypertension. It is the ethyl ester prodrug of methyldopa, an α2-adrenergic agonist stimulating central α2-adrenergic receptors and decreasing sympathetic outflow as well as blood pressure.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
239.12
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
0.92
TPSA
92.78
Fraction CSP3
0.42
Chiral centers
1.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
hypertension
Therapeutic Class
Cardiovascular Agents
Pathway
GPCR/G protein
Neuronal Signaling
Target
Adrenergic Receptor
Source data
