General
Preferred name
NAFTIFINE
Synonyms
Naftifungin ()
Naftifine HCl ()
Naftin ()
Exoderil ()
NAFTIFINE HYDROCHLORIDE ()
Naftifine (hydrochloride) ()
Naftifine (hydrochloride) ()
NAFT-900 ()
NAFT900 ()
NSC-760068 ()
AW 105-843 ()
Naftifina ()
AW-105-843 ()
Naft-500 ()
Naftifine-d3 (hydrochloride) ()
P&D ID
PD013168
CAS
65473-14-5
65472-88-0
1246833-81-7
Tags
available
drug
Approved by
FDA
First approval
1988
Drug indication
Dermatomycosis
Tinea pedis
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Naftifine hydrochloride is an antibiotic. Naftifine hydrochloride has antifungal activity against dermatophytes, aspergilli, Sporothrix schenckii, and yeasts of the genus Candida. Naftifine hydrochloride can be used for the research of superficial dermatomycoses inhibition[1].
PRICE
29
DESCRIPTION
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2, 3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride (Naftifine HCl) can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Naftifine is a topical, synthetic, broad spectrum allylamine derivate. It has antifungal, antibacterial and anti-inflammatory activity and is used for the treatment of tinea pedis, tinea cruris, and tinea corporis. It can be fungicidal or fungistatic depending on the concentration and the organisms involved. It appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2,3-epoxidase. It was developed by Merz pharma and has been listed.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
18
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Molecular Weight
287.17
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.99
TPSA
3.24
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Microbiology/virology
Stem Cells
Anti-infection
MOA
Hedgehog/Smoothened agonist
fungal squalene epoxidase inhibitor
Indication
tinea pedis, tinea cruris, tinea corporis
Target
antibiotic
Fungal
Smoothened
Therapeutic Class
Antifungal Agents
Solubility
Soluble in DMSO, not in water
Source data
