General
Preferred name
PRONETALOL
Synonyms
PRONETALOL HYDROCHLORIDE ()
Pronethalol hydrochloride ()
(¡À)-Pronethalo ()
(??)-Pronethalo ()
pronethalol ()
(±)-Pronethalo ()
Inetol ()
AY 6204 FREE BASE ()
ICI-38174 FREE BASE ()
COMPOUND 38174 ()
GNF-Pf-2670 ()
Naphthylisoproterenol ()
ICI 38174 FREE BASE ()
AY-6204 FREE BASE ()
Dl-pronethalol ()
AY-6204 HCL ()
P&D ID
PD013154
CAS
54-80-8
51-02-5
325-16-6
Tags
available
drug
Drug Status
approved
withdrawn
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Pronethalol ((¡À)-Pronethalo) is a non-selective ¦Â-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs)[1][2].
PRICE
34
DESCRIPTION
Pronethalol ((??)-Pronethalol), a non-selective ??-adrenergic antagonist, effectively inhibits Sox2 expression and offers protection against Digitalis-induced ventricular arrhythmias. Additionally, it can reverse such arrhythmias and limit the development of cerebral arteriovenous malformations (AVMs) [1] [2].
DESCRIPTION
β antagonist
(Tocriscreen Total)
DESCRIPTION
Pronethalol hydrochloride is a β-adrenergic antagonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMatrix
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Tocriscreen Total
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
39
Molecular Weight
229.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.87
TPSA
32.26
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
C
Toxicity type
carcinogenicity
Target
Adrenergic Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data
