General
Preferred name
PIMETHIXENE
Synonyms
PIMETHIXENE MALEATE ()
Pimetixene maleate ()
Calmixen ()
Pimetixene ()
BP-400 ()
BP 400 ()
Calmixene ()
NSC-757828 ()
Pimetixeno ()
P&D ID
PD013146
CAS
314-03-4
13187-06-9
Tags
available
drug
Drug Status
approved
investigational
Max Phase
2.0
Drug indication
allergic disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.;Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].
PRICE 41
PRICE 45
DESCRIPTION Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2, and can be used in studies of dry and irritant cough in children. irritant cough in children. (TargetMol Bioactive Compound Library)
DESCRIPTION Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively). (TargetMol Bioactive Compound Library)
Compound Sets
13
ChEMBL Drugs
CHEMBL152408
Drug Repurposing Hub
DrugBank
DB13292
DrugBank Approved Drugs
DB13292
DrugCentral
2169
DrugCentral Approved Drugs
2169
DrugMatrix
MedChem Express Bioactive Compound Library
HY-B1101A
NPC Screening Collection
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
pimethixene-maleate
TargetMol Bioactive Compound Library
T12489L
T12489
The Spectrum Collection
External IDs
44
Properties
(calculated by RDKit )
Molecular Weight
293.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
4.68
TPSA
3.24
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
1
styrene_B(8)
c:1:c:c-2:c(:c:c:1)-[#6](-c:3:c(-[$([#16;X2]),$([#6;X4])]-2):c:c:[c;!H0,$(c-[#17]),$(c-[#6;X4])](:c:3))=[#6]-[#6]
PAINS Family C
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
GPCR/G protein
Immunology/Inflammation
Neuroscience
Target
AChE
Dopamine Receptor
mAChR
5-HT Receptor
Histamine Receptor
5-HT Receptor,AChR,Adrenergic Receptor,Dopamine Receptor,Histamine Receptor
5-HT
D2
M1 mAChR
M2 mAChR
5-HT1A
5-HT2A
5-HT2B
5-HT2C
D4.4 receptor
H1 receptor
Indication
attention-deficit/hyperactivity disorder (ADHD), anxiety, sleep cycle support, allergic rhinitis
Disease Area
neurology/psychiatry, allergy
MOA
antihistamine
Source data