General
Preferred name
pentoxyverine
Synonyms
CARBETAPENTANE CITRATE ()
CARBETAPENTANE ()
Pentoxyverine Citrate ()
Pentoxyverine (citrate) ()
Carbetapentane (citrate) ()
Pentoxyverine, CB ()
Loucarbate ()
Pentoxyverine hydrogen citrate ()
NSC-757833 ()
Toclase ()
Sedotussin ()
Pentoxiverina ()
P&D ID
PD013138
CAS
23142-01-0
77-23-6
Tags
available
drug
Approved by
FDA
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Drug indication
sinusitis
Cough
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for ¦Ò1, ¦Ò2 and guinea-pig brain membrane ¦Ò1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[1][2][3][4].
PRICE 29
DESCRIPTION Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for ¦Ò1, ¦Ò2 and guinea-pig brain membran ¦Ò1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[1][2][3][4].
PRICE 30
DESCRIPTION Carbetapentane is an antitussive anticonvulsant non-opiod agonist that acts on sigma sites.
DESCRIPTION High affinity σ1 ligand (Tocriscreen Total)
DESCRIPTION Opioid receptor ligand with high affinity toward sigma1 sites; antitussive (LOPAC library)
DESCRIPTION Pentoxyverine Citrate is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold.It is sold over-the-counter in the United States as Solotuss,or in combination with other medications, especially decongestants. (BOC Sciences Bioactive Compounds)
DESCRIPTION Carbetapentane citrate (Pentoxyverine citrate) , an antitussive (cough suppressant), is frequently used for a cough related to illnesses like the common cold. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
23
BOC Sciences Bioactive Compounds
pentoxyverine-citrate-cas-23142-01-0-367306
Cayman Chemical Bioactives
18606
ChEMBL Approved Drugs
CHEMBL1256696
CHEMBL73234
ChEMBL Drugs
CHEMBL1256696
CHEMBL73234
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB11186
DrugBank Approved Drugs
DB11186
DrugCentral
494
DrugCentral Approved Drugs
494
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100566
Ki Database
CARBETAPENTANE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1256696
CHEMBL73234
MedChem Express Bioactive Compound Library
HY-B1055
HY-134004
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
carbetapentane
TargetMol Bioactive Compound Library
T0464
The Spectrum Collection
Tocriscreen Total
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
333.23
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
1
cLogP
3.4
TPSA
38.77
Fraction CSP3
0.65
Chiral centers
0.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
sigma1
Target
AChR
CHRM2
mAChR
Sigma Receptor
Indication
common cold, nasal congestion, bronchitis
Disease Area
otolaryngology, pulmonary
MOA
acetylcholine receptor antagonist
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data