General
Preferred name
DINOPROST
Synonyms
CHEMBL815 ()
Prostaglandin F2a tromethamine salt ()
PGF2¦Á THAM ()
Prostaglandin F2¦Á THAM ()
Prostaglandin F2a ()
PGF2¦Á ()
PGF2?? THAM ()
Prostaglandin F2?? THAM ()
Dinoprost tromethamine salt ()
Dinolytic ()
Zinoprost ()
Prostin F2 alpha ()
DINOPROST TROMETHAMINE ()
Prostaglandin F2alpha ()
PGF2?? ()
Dinoprost trometamol ()
Prostaglandin F2α ()
PGF2α ()
Prostaglandin F2α (tromethamine salt) ()
PGF2α THAM ()
Prostaglandin F2α THAM ()
PGF2Alpha ()
[3H]PGF2alpha ()
Dinoprost (tromethamine salt) ()
Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol ()
PGF2A THAM ()
U-14-583E ()
PGF2ALPHA THAM ()
U-14,583E ()
Lutalyse ()
Dinoprost Trometamol ()
PGF2A ()
NSC-196515 ()
U-14583E ()
Prostaglandin F 2 Alpha ()
PGF2α ()
PROSMON ()
PROSTAGLANDIN F2-ALPHA ()
Prostaglandin F2.alpha. ()
U-14,583 ()
U-14583 ()
[3H]PGF2α ()
Prostaglandin F2.alpha. (tromethamine salt) ()
Prostaglandin F2.alpha.-d4 ()
Prostaglandin F2.alpha.-d9 ()
P&D ID
PD013129
CAS
38562-01-5
36300-07-9
13535-33-6
551-11-1
34210-11-2
Tags
available
drug
drug candidate
probe
Approved by
FDA
First approval
1976
1982
Drug indication
Discovery agent
Abortion
Solid tumour/cancer
Prostaglandin
Oxytocic
Drug Status
withdrawn
approved
vet_approved
investigational
Max Phase
4.0
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PGF2α is a naturally-occurring prostanoid which functions as a potent vasoconstrictor. The synthetically produced drug, dinoprost, is chemically identical to the endogenous prostaglandin . (GtoPdb)
DESCRIPTION High affinity, selective AT1 antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
25
Cayman Chemical Bioactives
16020
10008643
316010
16010
ChEMBL Approved Drugs
CHEMBL1200896
CHEMBL815
ChEMBL Drugs
CHEMBL1200896
CHEMBL815
Concise Guide to Pharmacology 2017/18
1884
1957
Concise Guide to Pharmacology 2019/20
1884
1957
Concise Guide to Pharmacology 2021/22
1884
1957
Concise Guide to Pharmacology 2023/24
1884
1957
Drug Repurposing Hub
DrugBank
DB01160
DB12789
DrugBank Approved Drugs
DB01160
DB12789
DrugCentral
912
DrugCentral Approved Drugs
912
DrugMAP
DMXQKSL
DM4XAU7
DMPE1B2
DrugMAP Approved Drugs
DMXQKSL
EUbOPEN Chemogenomics Library
EUB0000405
Guide to Pharmacology
1884
1957
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL815
MedChem Express Bioactive Compound Library
HY-12956A
HY-12956
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Selleckchem Bioactive Compound Library
dinoprost-tromethamine
TargetMol Bioactive Compound Library
T4546
Tocris Bioactive Compound Library
4214
Tool Compound Set
Withdrawn 2.0
418
External IDs
89
Properties
(calculated by RDKit )
Molecular Weight
354.24
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
12
Ring Count
1
Aromatic Ring Count
0
cLogP
3.04
TPSA
97.99
Fraction CSP3
0.75
Chiral centers
5.0
Largest ring
5.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Prostanoid FP receptor
PEG
PTGDR, PTGDR2, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, TBXA2R
Endogenous Metabolite
Pathway
GPCR/G protein
Apoptosis
Autophagy
Metabolic Enzyme/Protease
Primary Target
Prostanoid Receptors
MOA
Prostaglandin Receptor
Agonist
Prostaglandin F2-alpha agonist
prostacyclin analog
Member status
member
Indication
labor induction
ATC
G02AD01
Therapeutic Class
Abortifacient Agents
Recommended Cell Concentration
None
Source data