General
Preferred name
Catharanthine
Synonyms
(+)-3, 4-Didehydrocoronaridine ()
(+)-3,4-Didehydrocoronaridine(+)-3, 4-Didehydrocoronaridine ()
Catharanthine (Tartrate) ()
(+)-3,4-Didehydrocoronaridine (Tartrate) ()
Catharanthine hemitartrate ()
Catharanthine sulfate ()
Catharanthine Tartrate(2468-21-5(free base)) ()
CATHARANTHINE BASE ()
P&D ID
PD013110
CAS
4168-17-6
2468-21-5
70674-90-7
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
90
DESCRIPTION
Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Tartrate has IC50s of 220 ¦ÌM and 8 ¦ÌM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity[1][2].
DESCRIPTION
Catharanthine Tartrate is a natural product isolated from Madagascar periwinkle, Catharanthine Tartrate inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pressure-lowering activity
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
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Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
40
Molecular Weight
336.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
2
cLogP
3.18
TPSA
45.33
Fraction CSP3
0.48
Chiral centers
4.0
Largest ring
7.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
L-type calcium channel
Calcium Channel
AChR
MOA
tubulin polymerization inhibitor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Source data
