General
Preferred name
LOMERIZINE
Synonyms
LOMERIZINE HYDROCHLORIDE ()
Terranas ()
Lomerizine 2HCl ()
KB-2796 ()
LOMERIZINE DiHCl101477-54-7 ()
Lomerizine dihydrochloride ()
Lomerizina ()
Lomerizine (hydrochloride) ()
P&D ID
PD013067
CAS
101477-55-8
101477-54-7
Tags
available
drug
Drug indication
Migraine
Drug Status
approved
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels.
PRICE
29
DESCRIPTION
Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Lomerizine is a diphenylmethylpiperazine Ca2+ channel blocker that helps prevent migraines. It inhibits sodium channel protein type 9 subunit alpha and voltage-dependent P/Q-type calcium channel subunit alpha-1A.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
468.22
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
4.9
TPSA
34.17
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
L-type calcium channel
T-type calcium channel
CACNA1B, SCN5A
Member status
member
MOA
P-Glycoprotein (MDR-1) Inhibitors
Calcium Channel Blockers
calcium channel blocker
Indication
migraine headache
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Source data
